IL-12 Induces Monocyte IL-18 Binding Protein Expression Via IFN-γ

Protein Expression Via IFN- IL-12 Induces Monocyte IL-18 Binding

IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.

Interferon-γ (IFN-γ) production by natural killer (NK) cells and cytotoxic lymphocytes is a key component of innate and adaptive immune responses. Because inhibitor of κB-ζ (IκBζ), a Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) inducible transcription factor, regulates IFN-γ production in KG-1 cells, we tested IκBζ's role in the classic lymphocyte pathway of IL-12/IL-18-induced IFN-γ...

Analysis Tissue Expression of IFN-γ in IL-12 and/or IL-18 Gene Ablated Naïve Mice

Interleukin 12 (IL-12) and/or interleukin 18 (IL-18) gene ablated mice were applied for the investigation of the tissue expression of interferon γ (IFN-γ). For IL-12, IL-18, IL-12/18 and wt mice, reproductive performance were recorded and IFN-γ concentrations in heart, lung, liver, spleen, kidney and serum were quantified by ELISA. There were no significant differences of IFN-γ in heart, lung a...

IFN-g-Inducing Factor/IL-18 Administration Mediates IFN-g- and IL-12-Independent Antitumor Effects

Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity

Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end,...